Saturday, 17 September 2011

No, they aren't pure either

Broken Hill skull from Zambia, dated to 110,000 BP. It is often identified as a Homo sapiens, largely because it is so recent. We now have evidence that very archaic hominins inhabited central and southern Africa at least 35,000 years ago.

The past year has brought us a new model of human evolution. It’s a modified version of “Out of Africa.” Present-day humans are now traced to a small founder group that began to expand some 80,000 years ago in East Africa and started to spread out of Africa some 50,000 to 40,000 years ago. Meanwhile, these early modern humans intermixed to varying degrees with the archaic hominins they replaced. There is thus 1 to 4% Neanderthal admixture in present-day Europeans and Asians, and 8% Neanderthal and “Denisovan” admixture in Melanesians (Green et al., 2010; Reich et al., 2010).

What about Africans? Are they the only “pure” humans? This is unlikely on theoretical grounds, as Hammer et al. (2011) point out in a newly released paper:


[…] the greatest opportunity for introgression was in Africa, where AMH [anatomically modern humans] and various archaic forms coexisted for much longer than they did outside of Africa. Indeed, the fossil record indicates that a variety of transitional forms with a mosaic of archaic and modern features lived over an extensive geographic area from Morocco to South Africa between 200 and 35 kya.

Africa’s warm climate tends to break down DNA quite rapidly. So we’ll probably never get to reconstruct an archaic African genome from a tooth or a skeletal fragment. But we can look through modern African genomes for signs of introgression from an archaic source. The most telltale signs are unusual polymorphisms in noncoding regions.

Using this approach, Hammer et al. (2011) assign about 2% of the modern African genome to an archaic population that split from ancestral modern humans some 700,000 years ago. This admixture is dated to about 35,000 years ago and may have occurred in Central Africa, since the level of admixture is highest in pygmy groups from that region.

Who exactly were these archaics?

Beginning ≈700 kya, fossil evidence from many parts of Africa indicate that Homo erectus was giving way to populations with larger brains, a change that was accompanied by several structural adjustments to the skull and postcranial skeleton (14). By ≈200 kya, individuals with more modern skeletal morphology begin to appear in the African record (8, 14). Despite these signs of anatomical and behavioral innovation, hominins with a combination of archaic and modern features persist in the fossil record across sub-Saharan Africa and the Middle East until after ≈35 kya […] Interestingly, recent studies attest to the existence of Late Stone Age human remains with archaic features in Nigeria (Iwo Eleru) and the Democratic Republic of Congo (Ishango) (Hammer et al., 2011)

Did Homo erectus linger in parts of Africa until as late as 35,000 years ago? The idea is no longer science fiction. We have the example of the “hobbits”—a Homo erectus population that lasted at least as long in Southeast Asia.

Perhaps we should take a second look at the Broken Hill skull, which was found near Kabwe, Zambia and has been dated to 110,000 BP (Bada et al., 1974). Many anthropologists have raised it to sapiens status, largely on the assumption that non-sapiens were no longer around at that time. Yet it doesn’t look at all like a Homo sapiens.

Admixture with late archaics

Broken Hill man probably occupied one end of a range of archaic groups that inhabited Africa on the eve of the ‘big bang’—the demic expansion of early modern humans that began 80,000 years ago somewhere in East Africa. At the other end were late archaic hominins who looked just like early modern humans but still lacked some of the final changes to their neural wiring.

If sub-Saharan Africans have about 2% admixture from Homo erectus, they probably have much more from late archaic hominins, who were more numerous and behaviorally more similar. How great is this late archaic admixture?

According to Watson et al. (1997), about 13% of the sub-Saharan gene pool comes from a demic expansion c. 111,000 years ago that corresponds to the entry of Skhul-Qafzeh hominins into the Middle East. Although these hominins were almost anatomically modern, their technology was Mousterian and differed little from that of Neanderthals.

Some last-minute neural changes seem to have occurred between this expansion 111,000 years ago and the ‘big bang’ 80,000 years ago. Perhaps these changes triggered the second expansion. As Atkinson et al. (2009) write:

[…] the African exodus was predated by a cultural revolution involving new stone blade technologies, skin working tools, ornaments and imported red ochre […] More advanced symbolic systems in language and religious beliefs could have provided a competitive advantage to a group by promoting coordination and cohesion.

What does it all mean?

It’s interesting that we have varying degrees of archaic admixture. But what does it all mean? Did these different admixtures make us different in different ways?

A traditional evolutionist would answer ‘no.’ As Ernst Mayr (1970, p. 80) wrote:

The claim has been made that species owe much of their genetic variability to introgressive hybridization. However, all the evidence contradicts this conclusion so far as animals is concerned. Not only are F1 hybrids between good species very rare, but where they occur the hybrids (even when not sterile) are demonstrably of inferior viability. The few genes that occasionally introgress into the parental species are not coadapted […] and are selected against. Introgressive hybridization seems to be a negligible source of genetic variation in animals.

In opposition to this view, Greg Cochran and John Hawkes have argued that gene introgression enabled early modern humans to adapt more quickly to new environments. Instead of starting from scratch, they just ‘cherry-picked’ genes that had already been developed by the populations they were replacing.

All of this assumes there were cherries worth picking. Did archaic hominins have anything useful to offer? Modern humans and Neanderthals adapted to the same cold environment but they did so in very different ways. The former, for instance, made tailored clothing while the latter were probably as furry as bears.

The stage whisper is that the Neanderthals gave ancestral Europeans special brain genes, notably the latest microcephalin variant (Hawkes et al., 2008). We now know otherwise. The reconstructed Neanderthal genome has revealed no brain genes that our ancestors cherry-picked. As for African archaic hominins, it’s even less clear what they had to offer. These were groups that lived under similar climatic and ecological conditions.

The cherry-picking theory seemed like a great idea. How else could one explain the sudden cultural dynamism of early modern humans? This effervescence began only 30,000 to 20,000 years ago—long after the ‘big bang.’ And it was most evident in southwestern France—a place far from East Africa. Surely the simplest explanation is gene introgression from European Neanderthals.

Well, things are never as simple as they seem. There are in fact other explanations:

1. Southwestern France has provided so many early European artifacts in part because it had so many early Europeans. It benefited from an unusually rich environment that could support a large population of semi-sedentary hunter/fisher/gatherers (Mellars, 1985).

2. France is a country with strong grassroots interest in history and prehistory. This is unfortunately not so elsewhere in the world, where the remote past is often viewed with indifference. Why does so much of our knowledge of the prehistoric Middle East come from Israel? Because Israel is chock-full of archeologists who do their work passionately and, in many cases, for free. We view human prehistory through the lens of present-day interests.

3. Actually, there is evidence of technological complexity almost at the epicenter of the ‘big bang.’ Central African sites have yielded fine tools, dated to c. 90,000 BP, that look just like Aurignacian tools from post-Neanderthal Europe (Brooks et al., 1995; Yellen et al., 1995).

References

Atkinson, Q.D., R.D. Gray, and A.J. Drummond. (2009). Bayesian coalescent inference of major human mitochondrial DNA haplogroup expansions in Africa, Proceedings of the Royal Society B, 276, 367–373

Bada, J.L., R.A. Schroeder, R. Protsch, & R. Berger. (1974). Concordance of Collagen-Based Radiocarbon and Aspartic-Acid Racemization Ages, Proceedings of the National Academy of Sciences (USA), 71, 914-917.

Brooks, A.S., D.M. Helgren, J.S. Cramer, A. Franklin, W. Hornyak, J.M. Keating, R.G. Klein, W.J. Rink, H. Schwarcz, J.N. Leith Smith, K. Stewart, N.E. Todd, J. Verniers, & J.E. Yellen. (1995). Dating and context of three Middle Stone Age sites with bone points in the Upper Semliki Valley, Zaire, Science, 268, 548-553.

Green, R.E., J. Krause, A.W. Briggs, T. Maricic, U. Stenzel, M. Kircher, et al. (2010). A draft sequence of the Neandertal genome, Science, 328, 710-722.
http://www.sciencemag.org/cgi/reprint/328/5979/710.pdf

Hammer, M.F., A.E. Woerner, F.L. Mendez, J.C. Watkins, and J.D. Wall. (2011). Genetic evidence for archaic admixture in Africa, Proceedings of the National Academy of Science (USA), early edition,
www.pnas.org/cgi/doi/10.1073/pnas.1109300108

Hawks, J., G. Cochran, H.C. Harpending, & B.T. Lahn (2008). A genetic legacy from archaic Homo, Trends in Genetics, 24, 19-23.

Mayr, E. (1970). Populations, Species, and Evolution, Belknap Press: Cambridge (Mass.)

Mellars, P.A. (1985). The ecological basis of social complexity in the Upper Paleolithic of Southwestern France. In Prehistoric Hunter‑Gatherers. The Emergence of Cultural Complexity, T.D. Price & J.A. Brown (Eds.). Orlando: Academic Press, pp. 271‑297.

Reich, D., R.E. Green, M. Kircher, J. Krause, N. Patterson, E.Y. Durand, et al. (2010). Genetic history of an archaic hominin group from Denisova Cave in Siberia, Nature, 468, 1053-1060.

Watson, E., P. Forster, M. Richards, and H-J. Bandelt. (1997). Mitochondrial footprints of human expansions in Africa, American Journal of Human Genetics, 61, 691-704.

Yellen, J.E., A.S. Brooks, E. Cornelissen, M.J. Mehlman, & K. Stewart. (1995). A Middle Stone Age worked bone industry from Katanda, Upper Semliki Valley, Zaire, Science, 268, 553-556.

9 comments:

Tod said...

Chris Stringer was on BBC radio talking about the 13,000-year-old Iwo Eleru skull this morning. He did his Phd on it, now it has suddenly become apparent that it looks primitive.

It all depends how common hybridization was. A modern human who resorted to mating with an archaic would be one rejected as a mate by other modern humans and be of poor genetic quality. So the hybrid would have a lot stacked up against it. But if the dice were thrown often enough..

Tod said...

GC & HH ' purely hypothetical' example of a mental faculty of Neanderthals which could have been useful in moderns is anticipating the movements of a prey animal so as to avoid getting stomped or gored.

I think Neanderthals lay in ambush and popped up to surround their prey. So if the Neanderthals possessed a special form of spatial awareness/(TOM) it would be to let them anticipate the escape route of the prey in order to deliberately get in the way of the animal in such a way so that the animal would run onto the Neanderthal's stabbing spear.
A Russian site (Here) claims that - The ancient hunter could have crawled towards an animal as close as possible, and then had run as fast as he could, throwing a javelin, while running. However, a heavy spear is much more effective at small distances, than a light javelin. Calculations show that Neanderthal men had been able to cover 15-20 meters within 1-2 seconds, which is enough for a unexpected and successful attack. This means that Homo neanderthalensis were fast and accurate hunters, not clumsy snails as some may think.

I think that is nonsense, even if the animals did not hear or smell the hunters approach. The final rush would immediately startle the prey into flight., No human could cover 15-20 meters fast enough to catch a wild animal stationary (if he could catch it at all, which I doubt). The lumbering Neanderthals certainly couldn't as they lacked the inner ear structure indecative of that kind of agility. An attempt to rush at and spear an animal which would be moving away from the hunter would result in a the spear strike with very little actual velocity.

The pattern of injuries in Neanderthals is support for the Neanderthals strategy having been to lurk around the game trails in wait for a prey animal to walk into a prepared ambush, then popping up to surround their prey and spear it as it tried to burst through the cordon.

The technological complexity of the steppe-tundra inhabitants, was it a big step up from previous human achievement ?

Peter Frost said...

Tod,

I suspect the introgression from Homo erectus to Homo sapiens was mediated by a third party, i.e., a late archaic group.

As for the cherry-picking hypothesis, there no longer seems to be any room for debate. We now have the Neanderthal genome. Where are the cherries?

Tod said...

Maybe the cherry picked genes have altered so that they are difficult to identify as Neanderthal.

The geneticists say the mtDNA of today's Europeans is totally different from Ice age North Europeans, conclusive proof that the Ice age people of Europe died out and were replaced by ME farmers. Well so much the worse for the geneticists! I know that they're wrong about that. And if mtDNA (which is said to not be subject to natural selection) can evolve over time in that way nuclear DNA certainly can too.

-----------------------------------
Why were Neanderthals red haired, something to do with Vitamin D right ? No they were woodland ambush predators so evolved a furry camouflage suit . "Orangutans are greatly camouflaged in rainforests because of the little sunlight that filters through the dense canopy reflects green light and absorbs the red-orange light that is similar to the color of the Orangutan's coat"

Ben10 said...

What fascinates me is that number, 4%. That's huge. To reach that number today, a high proportion of earlyer sapiens must have kept an even higher proportion of neanderthal genes for a very long time.

"la guerre du feu' from JJ Anauld, initially looking naivelly ireallistic with all its different looking people, seems more and more plausible:
At this time, all the tribes in your neighbourhood would look distinct from each other, with all sort of different atavisms in each of them.

Tod said...

"It’s interesting that we have varying degrees of archaic admixture. But what does it all mean? Did these different admixtures make us different in different ways?"

One interperetation could be that Europeans are purer (ie relatively speaking). Melanesians have the most archiac admixture found so far and (IMO) all that admixture hasn't noticably helped or hindered them. So that leaves the challenge presented by the conditions of life as the key factor in driving evolution.

Nanonymous said...

Just "wow" at the pictured skull. Seriously, someone had a gall to assign it to the same species as modern humans? Nothing is impossible in anthropology, it seems.

Anonymous said...

I think people really need to think about how they are defining human and what is pure.

Basically to define *human* we should look at what people you want to call human and see what they have in common.

It seems that all humans have an element of that 80kya East African (EA) population but there is no reason to think that those closest to that population are the *most* human. That would just be pointless... It would be just as fair to blindly say those with only half EA are the *most* human. How much the EA element varies is trivial, apart from zero. The reason it would be strange to define those fully decended from EA as *most* human is because it would be using a trivial method and a method that fails to describe an important commonality between most humans, namely having some neandertal. If I wanted to I could call the proto eurasian as most human and closeness to them as closeness to most human.

And BTW, the fact that ME neandertal mixed with humans means they were human!!!

Anonymous said...

Very late to the thread... but...

IF Hobbits survived on Flores long enough to overlap the modern humans (as described by the "Ebu Gogo" legends on Flores)...

AND Melanesians today have an exceptionally high level(8%)of archaic Denisovan DNA...

Could it be that the Hobbits of Flores, were simply insular dwarfed Denisovans... whose DNA introgressed into the founder population of Melanesia?